Abstract

More and more systematic reviews of diagnostic test accuracy studies are being published, but they can be methodologically challenging. In this paper, the authors present some of the recent developments in the methodology for conducting systematic reviews of diagnostic test accuracy studies. Restrictive electronic search filters are discouraged, as is the use of summary quality scores. Methods for meta-analysis should take into account the paired nature of the estimates and their dependence on threshold. Authors of these reviews are advised to use the hierarchical summary receiver-operating characteristic or the bivariate model for the data analysis. Challenges that remain are the poor reporting of original diagnostic test accuracy studies and difficulties with the interpretation of the results of diagnostic test accuracy research.

Keywords

MedicineTest (biology)Diagnostic testMeta-analysisBivariate analysisDiagnostic accuracySystematic reviewMedical physicsMEDLINEComputer scienceMachine learningPathologyPediatricsRadiology

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Publication Info

Year
2008
Type
article
Volume
149
Issue
12
Pages
889-897
Citations
1089
Access
Closed

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Cite This

Mariska Leeflang, Jonathan J Deeks, Constantine Gatsonis et al. (2008). Systematic Reviews of Diagnostic Test Accuracy. Annals of Internal Medicine , 149 (12) , 889-897. https://doi.org/10.7326/0003-4819-149-12-200812160-00008

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DOI
10.7326/0003-4819-149-12-200812160-00008