Abstract

& & .I & -Based on modeling experiment of buspirone we synthesized the sterically restricted analog, namely the piperidine 3,4-trans-amino amide (3).Preliminary biological evaluation is reported.The disclosure that buspirone (I), an anxiolytic drug, has high selective affinity for 5HTln recept~rsla~b led us to investigate the structural correlation between buspirone and the piperidine analog of 1,2-amino amide U-48,753 (2).

Keywords

BuspironePiperidineChemistrySteric effectsAmideDiamineStereochemistryDerivative (finance)AgonistOrganic chemistryReceptorBiochemistry

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Publication Info

Year
1994
Type
article
Volume
39
Issue
1
Pages
163-163
Citations
11
Access
Closed

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Jacob Szmuszkovicz, Shikai Zhao, Arun K. Ghosh et al. (1994). Synthetic Studies towards A trans-3,4-Diamine Derivative of Piperidine Mimicking Buspirone. Heterocycles , 39 (1) , 163-163. https://doi.org/10.3987/com-93-s(b)12

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DOI
10.3987/com-93-s(b)12