SWISS-PROT: Connecting Biomolecular Knowledge Via a Protein Database

Abstract

With the explosive growth of biological data, the development of new means of data storage was needed. More and more often biological information is no longer published in the conventional way via a publication in a scientific journal, but only deposited into a database. In the last two decades these databases have become essential tools for researchers in biological sciences. Biological databases can be classified according to the type of information they contain. There are basically three types of sequence-related databases (nucleic acid sequences, protein sequences and protein tertiary structures) as well as various specialized data collections. It is important to provide the users of biomolecular databases with a degree of integration between these databases as by nature all of these databases are connected in a scientific sense and each one of them is an important piece to biological complexity. In this review we will highlight our effort in connecting biological information as demonstrated in the SWISS-PROT protein database.

Keywords

Biological databaseDatabaseBiological dataComputer scienceProtein structure databaseBioinformaticsSequence databaseBiology

Affiliated Institutions

SIB Swiss Institute of Bioinformatics CH

Related Publications

The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003

Brigitte Boeckmann , Amos Bairoch , Rolf Apweiler +9 more

The SWISS-PROT protein knowledgebase (http://www.expasy.org/sprot/ and http://www.ebi.ac.uk/swissprot/) connects amino acid sequences with the current knowledge in the Life Scie...

2003 Nucleic Acids Research 3907 citations

NetAffx: Affymetrix probesets and annotations

G. Liu

NetAffx (http://www.affymetrix.com) details and annotates probesets on Affymetrix GeneChip microarrays. These annotations include (i) static information specific to the probeset...

2003 Nucleic Acids Research 486 citations

The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data

C. T. Porter

The Catalytic Site Atlas (CSA) provides catalytic residue annotation for enzymes in the Protein Data Bank. It is available online at http://www.ebi.ac.uk/thornton-srv/databases/...

2003 Nucleic Acids Research 608 citations

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

Konstantin Arnold , Lorenza Bordoli , Jürgen Kopp +1 more

Abstract Motivation: Homology models of proteins are of great interest for planning and analysing biological experiments when no experimental three-dimensional structures are av...

2005 Bioinformatics 7038 citations

Toward understanding the origin and evolution of cellular organisms

Minoru Kanehisa

Abstract In this era of high‐throughput biology, bioinformatics has become a major discipline for making sense out of large‐scale datasets. Bioinformatics is usually considered ...

2019 Protein Science 6016 citations

Publication Info

Year: 2001
Type: review
Volume: 3
Issue: 3
Pages: 47-55
Citations: 212
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

SWISS-PROT: Connecting Biomolecular Knowledge Via a Protein Database

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

212

OpenAlex

Cite This

APA Style

                            
                                    Elisabeth Gasteiger, 
                                
                                    E. Jung, 
                                
                                    Amos Bairoch
                                
                            (2001). 
                            SWISS-PROT: Connecting Biomolecular Knowledge Via a Protein Database. 
                            Current Issues in Molecular Biology
                            , 3
                            (3)
                            , 47-55.
                            https://doi.org/10.21775/cimb.003.047

Identifiers

DOI: 10.21775/cimb.003.047