Abstract

<p>Supplementary Figure S1 shows size exclusion chromatography profiles of products of the refolding reactions for p/MHCs utilized in this study. Supplementary Figure S2 shows binding properties of antibodies to sotorasib-KRAS(G12C) peptide conjugates in complex with MHCs over the course of the affinity maturation campaign. Supplementary Figure S3 shows binding profiles of a deep mutational scanning library before and after sorting. Supplementary Figure S4 shows HLA expression of cell lines. Supplementary Figure S5 shows cytotoxic effects of the R023 scDb on sotorasib-treated tumor cells. Supplementary Figure S6 shows binding analysis of “pan-HLA” antibody phage clones to p/MHC complexes. Supplementary Figure S7 shows binding analysis of antibody phage clones to an ibrutinib-BTK peptide conjugate in complex with MHC.</p>

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Year
2025
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article
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Takamitsu Hattori, Lorenzo Maso, Kiyomi Y. Araki et al. (2025). Supplementary Figures 1-7 from Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy. . https://doi.org/10.1158/2159-8290.30848943

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10.1158/2159-8290.30848943

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