Abstract
This mini-review describes the role of different mitochondrial components in the formation of reactive oxygen species under normal and pathological conditions and the effect of inhibitors and uncouplers on superoxide formation.
Keywords
SuperoxideRespiratory chainMitochondrial respiratory chainReactive oxygen speciesChemistryMitochondrionOxygenBiochemistryRespiratory systemBiologyEnzymeAnatomyOrganic chemistry
Affiliated Institutions
Related Publications
Free Radicals in the Physiological Control of Cell Function
At high concentrations, free radicals and radical-derived, nonradical reactive species are hazardous for living organisms and damage all major cellular constituents. At moderate...
6-Hydroxydopamine: Evidence for Superoxide Radical as an Oxidative Intermediate
Superoxide dismutase inhibited the autoxidation of 6-hydroxydopamine as measured by the rate of formation of a quinone and the rate of oxygen consumption. These observations dem...
Role of ubiquinone in the mitochondrial generation of hydrogen peroxide
Antimycin-inhibited bovine heart submitochondrial particles generate O2- and H2O2 with succinate as electron donor. H2O2 generation involves the action of the mitochondrial supe...
Univalent Reduction of Molecular Oxygen by Spinach Chloroplasts on Illumination
Spinach chloroplasts induced the photoreduction of cytochrome c and photooxidation of epinephrine, both of which depended on oxygen and were inhibited by superoxide dismutase.Th...
The Metabolic Fate of Mitochondrial Hydrogen Peroxide
Mitochondrial H 2 O 2 formation is not in equilibrium with defence mechanisms that counteract an accumulation of H 2 , in rat‐heart cell. A model for the accumulation kinetics i...
Publication Info
- Year
- 1997
- Type
- review
- Volume
- 17
- Issue
- 1
- Pages
- 3-8
- Citations
- 894
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
894
OpenAlex
Cite This
Julio F. Turrens
(1997).
Superoxide Production by the Mitochondrial Respiratory Chain.
Bioscience Reports
, 17
(1)
, 3-8.
https://doi.org/10.1023/a:1027374931887
Identifiers
- DOI
- 10.1023/a:1027374931887