Subgroup Analysis and Covariate Adjustment in Randomized Clinical Trials of Traumatic Brain Injury: A Systematic Review

Abstract

The reported covariate adjustment and subgroup analyses from TBI trials had several methodological shortcomings. Appropriate performance and reporting of covariate adjustment and subgroup analysis should be considerably improved in future TBI trials because interpretation of treatment benefits may be misleading otherwise.

Keywords

MedicineCovariateSubgroup analysisRandomized controlled trialGlasgow Outcome ScaleClinical trialMeta-analysisPhysical therapyTraumatic brain injuryInternal medicinePsychiatryStatistics

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Publication Info

Year: 2005
Type: review
Volume: 57
Issue: 6
Pages: 1244-1253
Citations: 50
Access: Closed

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APA Style

                            
                                
                                    Adrían V. Hernández, 
                                
                                    Ewout W. Steyerberg, 
                                
                                    Gillian S. Taylor
                                
                                et al.
                            
                            (2005). 
                            Subgroup Analysis and Covariate Adjustment in Randomized Clinical Trials of Traumatic Brain Injury: A Systematic Review. 
                            Neurosurgery
                            , 57
                            (6)
                            , 1244-1253.
                            https://doi.org/10.1227/01.neu.0000186039.57548.96
                        

Identifiers

DOI: 10.1227/01.neu.0000186039.57548.96