Abstract
was found in the soluble fraction of rat brain.Upon limited proteolysis by calcium-dependent protease occurring in the same tissue, the proenzyme was converted to an active protein kinase which could phosphorylate five species of histone fractions.Trypsin also catalyzed the conversion.
Keywords
ProteaseNucleotideCalciumCyclic nucleotideBiochemistryChemistryProtein kinase ACell biologyBiologyEnzymeGene
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Publication Info
- Year
- 1977
- Type
- article
- Volume
- 252
- Issue
- 21
- Pages
- 7610-7616
- Citations
- 864
- Access
- Closed
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Cite This
Masatoshi Inoue,
Akira Kishimoto,
Yoshimi Takai
et al.
(1977).
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain..
Journal of Biological Chemistry
, 252
(21)
, 7610-7616.
https://doi.org/10.1016/s0021-9258(17)41010-6
Identifiers
- DOI
- 10.1016/s0021-9258(17)41010-6