Abstract

As a compromise to the factors listed above, we propose using an open-reference method to enhance OTU stability. This type of method clusters sequences against a database and includes unmatched sequences by clustering them via a relatively stable de novo clustering method. OTU stability is an important consideration when analyzing microbial diversity and is a feature that should be taken into account during the development of novel OTU clustering methods.

Keywords

Operational taxonomic unitBiologyCluster analysisMicrobial ecologyIdentification (biology)Hierarchical clusteringOrdinationRibosomal RNAComputational biology16S ribosomal RNAEcologyEvolutionary biologyGeneticsArtificial intelligenceComputer scienceBacteria

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Year
2015
Type
article
Volume
3
Issue
1
Pages
20-20
Citations
180
Access
Closed

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Yan He, J. Gregory Caporaso, Xiaotao Jiang et al. (2015). Stability of operational taxonomic units: an important but neglected property for analyzing microbial diversity. Microbiome , 3 (1) , 20-20. https://doi.org/10.1186/s40168-015-0081-x

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DOI
10.1186/s40168-015-0081-x