Abstract
Spontaneous chromosomal aberrations may occur with a high frequency in human tissue culture cells, and the frequency increases with the age of the culture. In a series of experiments the frequency of aberrations found at anaphase and telophase increased from 3.6 per cent to 9.6 per cent as the culture aged over a period of three months. Most, or all, of the aberrations appear to be of the chromatid type, and must have originated at prophase of the nuclear cycle. There seems to be some correlation between the frequency of spontaneous chromosome aberrations and sensitivity to ionizing radiation in mammalian tissue culture cells.
Keywords
TelophaseChromatidBiologyAnaphaseTissue cultureMitosisChromosomeProphaseColchicineMetaphaseGeneticsMolecular biologyMeiosisIn vitro
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Publication Info
- Year
- 1961
- Type
- article
- Volume
- 95
- Issue
- 881
- Pages
- 97-102
- Citations
- 21
- Access
- Closed
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Cite This
Hally J. Sax,
Kari N. Passano
(1961).
Spontaneous Chromosome Aberrations in Human Tissue Culture Cells.
The American Naturalist
, 95
(881)
, 97-102.
https://doi.org/10.1086/282163
Identifiers
- DOI
- 10.1086/282163