Keywords
BiologyRNA interferenceGeneTransgeneRNA silencingMutantPhenotypeGene expressionCell biologyGeneticsRNAFunction (biology)EmbryoGene silencingSmall interfering RNA
Affiliated Institutions
Related Publications
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post...
Multiplex gene regulation: a two-tiered approach to transgene regulation in transgenic mice.
Transgenic mice have been used to study gene function and regulation by introducing inducible or tissue-specific transgenes. This approach is generally limited to studying gene ...
Human Embryonic Stem Cells Reprogram Myeloid Precursors Following Cell–Cell Fusion
Abstract Here, we examine the ability of undifferentiated human embryonic stem cells (hESCs) to reprogram the nuclei of hESC-derived myeloid precursors following cell–cell fusio...
Overexpression of <i>NANOG</i> in human ES cells enables feeder-free growth while inducing primitive ectoderm features
Human embryonic stem cells (HESCs) are pluripotent cells derived from the ICM of blastocyst stage embryos. As the factors needed for their growth are largely undefined, they are...
Interaction of R17 Coat Protein With Its RNA Binding Site For Translational Repression
The interaction between bacteriophage R17 coat protein and its RNA binding site for translational repression was studied as an example of a sequence-specific RNA-protein interac...
Publication Info
- Year
- 1999
- Type
- article
- Volume
- 2
- Issue
- 2
- Pages
- 70-75
- Citations
- 720
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
720
OpenAlex
Cite This
Florence Wianny,
Magdalena Zernicka‐Goetz
(1999).
Specific interference with gene function by double-stranded RNA in early mouse development.
Nature Cell Biology
, 2
(2)
, 70-75.
https://doi.org/10.1038/35000016
Identifiers
- DOI
- 10.1038/35000016