Specific Detection of <scp>d</scp>-Glucose by a Tetraphenylethene-Based Fluorescent Sensor

Abstract

A conceptually new "light-up" biosensor with a high specificity for d-glucose (Glu) in aqueous media has been developed. The emission from a tetraphenylethene (TPE)-cored diboronic acid (1) was greatly boosted when the fluorogen was oligomerized with Glu because of restriction of the intramolecular rotations of the aryl rotors of TPE by formation of the oligomer. Little change in the light emission was observed when 1 was mixed with D-fructose, D-galactose, or D-mannose, as these saccharides are unable to oligomerize with the fluorogen.

Keywords

ChemistryOligomerFluorescenceIntramolecular forceAqueous solutionFructoseMannoseBiosensorAqueous mediumGalactoseCombinatorial chemistryStereochemistryPolymer chemistryOrganic chemistryBiochemistry

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Publication Info

Year: 2010
Type: article
Volume: 133
Issue: 4
Pages: 660-663
Citations: 577
Access: Closed

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APA Style

                            
                                
                                    Yi Liu, 
                                
                                    Chunmei Deng, 
                                
                                    Li Tang
                                
                                et al.
                            
                            (2010). 
                            Specific Detection of <scp>d</scp>-Glucose by a Tetraphenylethene-Based Fluorescent Sensor. 
                            Journal of the American Chemical Society
                            , 133
                            (4)
                            , 660-663.
                            https://doi.org/10.1021/ja107086y
                        

Identifiers

DOI: 10.1021/ja107086y