Somatic Mutation Profiles of MSI and MSS Colorectal Cancer Identified by Whole Exome Next Generation Sequencing and Bioinformatics Analysis

Abstract

We conclude that with deep sequencing of tumor exomes one may be able to predict the microsatellite status of CRC and in addition identify potentially clinically relevant mutations.

Keywords

Microsatellite instabilityExome sequencingBiologyGermline mutationColorectal cancerGeneticsCancerExomeMLH1GermlineMutationBioinformaticsComputational biologyMicrosatelliteDNA mismatch repairGene

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Publication Info

Year: 2010
Type: article
Volume: 5
Issue: 12
Pages: e15661-e15661
Citations: 239
Access: Closed

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APA Style

                            
                                
                                    Bernd Timmermann, 
                                
                                    Martin Kerick, 
                                
                                    Christina Roehr
                                
                                et al.
                            
                            (2010). 
                            Somatic Mutation Profiles of MSI and MSS Colorectal Cancer Identified by Whole Exome Next Generation Sequencing and Bioinformatics Analysis. 
                            PLoS ONE
                            , 5
                            (12)
                            , e15661-e15661.
                            https://doi.org/10.1371/journal.pone.0015661
                        

Identifiers

DOI: 10.1371/journal.pone.0015661