Single-cell transcriptomics unveils atrazine's impact on neurons and microglia in C57BL/6 mice

Yingjie Zhou; Mi Pan; Zhiwei Zheng; Jiang Wei; Tianyu Sun; Yongjie Ma; Yan Sun

doi:10.1016/j.ecoenv.2025.119545

Abstract

Environmental ATZ exposure triggers PD-like neurodegeneration through dual mechanisms: (1) neuronal calcium dysregulation inducing oxidative stress and (2) microglia-driven neuroimmune dysfunction via CX3CL1 signaling. This study provides the novel mechanistic evidence linking ATZ to PD-like pathology via neuron-microglia crosstalk, highlighting the need for re-evaluating global ATZ exposure guidelines.

Affiliated Institutions

Guilin Medical University CN

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Publication Info

Year: 2025
Type: article
Volume: 309
Pages: 119545-119545
Citations: 0
Access: Closed

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APA Style

                            
                                    Yingjie Zhou, 
                                
                                    Mi Pan, 
                                
                                    Zhiwei Zheng
                                
                                et al.
                            
                            (2025). 
                            Single-cell transcriptomics unveils atrazine's impact on neurons and microglia in C57BL/6 mice. 
                            Ecotoxicology and Environmental Safety
                            , 309
                            
                            , 119545-119545.
                            https://doi.org/10.1016/j.ecoenv.2025.119545

Identifiers

DOI: 10.1016/j.ecoenv.2025.119545