Abstract
It has become clear in recent years that autophagy not only serves to produce amino acids for ongoing protein synthesis and to produce substrates for energy production when cells become starved but autophagy is also able to eliminate defective cell structures and for this reason the process may be implicated in several diseased states. Autophagy is controlled by complex signalling pathways, including that used by insulin. In these pathways, phosphatidylinositol 3-kinases and the protein kinase mTOR play important roles.
Keywords
AutophagyPI3K/AKT/mTOR pathwayCell biologyKinasePhosphatidylinositolSignalling pathwaysULK1BiologySignallingSignal transductionMechanistic target of rapamycinProtein kinase AChemistryBiochemistryApoptosis
MeSH Terms
AgingAnimalsAutophagyDiseaseHealthHumansSignal Transduction
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Publication Info
- Year
- 2006
- Type
- review
- Volume
- 27
- Issue
- 5-6
- Pages
- 411-425
- Citations
- 241
- Access
- Closed
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Cite This
Alfred J. Meijer,
Patrice Codogno
(2006).
Signalling and autophagy regulation in health, aging and disease.
Molecular Aspects of Medicine
, 27
(5-6)
, 411-425.
https://doi.org/10.1016/j.mam.2006.08.002
Identifiers
- DOI
- 10.1016/j.mam.2006.08.002
- PMID
- 16973212