Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease

Abstract

Cortical Aβ and tau pathology affects gray matter thinning within select neocortical regions and potentially contributes to downstream hippocampal degeneration. Neocortical Alzheimer's pathology is evident even amongst older asymptomatic individuals suggesting the existence of a preclinical phase of dementia.

Keywords

NeocortexHippocampal formationEntorhinal cortexNeurosciencePathologyParahippocampal gyrusAtrophyDementiaAlzheimer's diseasePsychologyCerebral cortexGrey matterMedicineWhite matterMagnetic resonance imagingTemporal lobeDiseaseEpilepsy

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Publication Info

Year: 2010
Type: article
Volume: 5
Issue: 9
Pages: e12853-e12853
Citations: 86
Access: Closed

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APA Style

                            
                                
                                    Rahul S. Desikan, 
                                
                                    Mert R. Sabuncu, 
                                
                                    Nicholas J. Schmansky
                                
                                et al.
                            
                            (2010). 
                            Selective Disruption of the Cerebral Neocortex in Alzheimer's Disease. 
                            PLoS ONE
                            , 5
                            (9)
                            , e12853-e12853.
                            https://doi.org/10.1371/journal.pone.0012853
                        

Identifiers

DOI: 10.1371/journal.pone.0012853