Abstract
Many substances used in daily life, such as coffee, alcohol, and pharmaceutical treatment for hypertension, have been accused of "menace" in causing cancer or other major diseases. Although some of the accusations have subsequently been refuted or withdrawn, they have usually been based on statistical associations in epidemiologic studies that could not be done with the customary experimental methods of science. With these epidemiologic methods, however, the fundamental scientific standards used to specify hypotheses and groups, get high-quality data, analyze attributable actions, and avoid detection bias may also be omitted. Despite peer-review approval, the current methods need substantial improvement to produce trustworthy scientific evidence.
Keywords
Affiliated Institutions
Related Publications
Comparative quantification of health risks : global and regional burden of disease attributable to selected major risk factors
During the last quarter of the twentieth century, a number of works have addressed both the methodological and empirical aspects of population-wide impacts of major causes of di...
Survey of review spam detection using machine learning techniques
Online reviews are often the primary factor in a customer’s decision to purchase a product or service, and are a valuable source of information that can be used to determine pub...
Meta-analysis Spurious precision? Meta-analysis of observational studies
In previous articles we have focused on the potentials, principles, and pitfalls of meta-analysis of randomised controlled trials.1 2 3 4 5 Meta-analysis of observational data i...
Nutrition and breast cancer
Epidemiologic evidence on the relation between nutrition and breast cancer is reviewed. After several decades of study, many aspects of the role of diet in breast cancer etiolog...
Guidelines for the Early Management of Adults With Ischemic Stroke
Purpose— Our goal is to provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke. The intended audience ...
Publication Info
- Year
- 1988
- Type
- review
- Volume
- 242
- Issue
- 4883
- Pages
- 1257-1263
- Citations
- 300
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1126/science.3057627