Abstract

A new scanning probe-based microrheology approach is used to quantify the frequency-dependent viscoelastic behavior of both fibroblast cells and polymer gels. The scanning probe shape was modified using polystyrene beads for a defined surface area nondestructively deforming the sample. An extended Hertz model is introduced to measure the frequency-dependent storage and loss moduli even for thin cell samples. Control measurements of the polyacrylamide gels compare well with conventional rheological data. The cells show a viscoelastic signature similar to in vitro actin gels.

Keywords

MicrorheologyViscoelasticityMaterials scienceRheologyPolymerPolystyrenePolyacrylamideComposite materialPolymer chemistry

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Year
2000
Type
article
Volume
85
Issue
4
Pages
880-883
Citations
501
Access
Closed

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Rachel Mahaffy, Chih‐Kang Shih, F. C. MacKintosh et al. (2000). Scanning Probe-Based Frequency-Dependent Microrheology of Polymer Gels and Biological Cells. Physical Review Letters , 85 (4) , 880-883. https://doi.org/10.1103/physrevlett.85.880

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DOI
10.1103/physrevlett.85.880