SARS-CoV-2 variants, spike mutations and immune escape

Keywords

BiologyAntigenicityContext (archaeology)MutationVirusGeneticsAntigenic variationPopulationVirologyCoronavirusViral evolutionImmune systemImmunityGeneDiseaseAntigenGenomeCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)Medicine

Affiliated Institutions

Related Publications

Antigenic and Immunogenic Characterization of Recombinant Baculovirus-Expressed Severe Acute Respiratory Syndrome Coronavirus Spike Protein: Implication for Vaccine Design

Yuxian He , Jingjing Li , Susanne Heck +2 more

ABSTRACT The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus (SARS-CoV) mediates the receptor interaction and immune recognition and is considered a majo...

2006 Journal of Virology 135 citations

NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

Mimi Guebre‐Xabier , Nita Patel , Jing-Hui Tian +10 more

There is an urgent need for a safe and protective vaccine to control the global spread of SARS-CoV-2 and prevent COVID-19. Here, we report the immunogenicity and protective effi...

2020 Vaccine 238 citations

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

Chien‐Te K. Tseng , Elena Sbrana , Naoko Iwata‐Yoshikawa +5 more

These SARS-CoV vaccines all induced antibody and protection against infection with SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type i...

2012 PLoS ONE 604 citations

Structural Basis of Neutralization by a Human Anti-severe Acute Respiratory Syndrome Spike Protein Antibody, 80R

W.C. Hwang , Yaqiong Lin , Eugenio Santelli +6 more

Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease that caused pandemic spread in 2003. The etiological agent of SARS is a novel coronavirus (SARS-Co...

2006 Journal of Biological Chemistry 231 citations

Structure, Function, and Evolution of Coronavirus Spike Proteins

Fang Li

The coronavirus spike protein is a multifunctional molecular machine that mediates coronavirus entry into host cells. It first binds to a receptor on the host cell surface throu...

2016 Annual Review of Virology 2888 citations

Publication Info

Year: 2021
Type: review
Volume: 19
Issue: 7
Pages: 409-424
Citations: 3699
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

SARS-CoV-2 variants, spike mutations and immune escape

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

3699

OpenAlex

Cite This

APA Style

                            
                                
                                    William T. Harvey, 
                                
                                    Alessandro M. Carabelli, 
                                
                                    Ben Jackson
                                
                                et al.
                            
                            (2021). 
                            SARS-CoV-2 variants, spike mutations and immune escape. 
                            Nature Reviews Microbiology
                            , 19
                            (7)
                            , 409-424.
                            https://doi.org/10.1038/s41579-021-00573-0
                        

Identifiers

DOI: 10.1038/s41579-021-00573-0