Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

Superoxide Dismutase

An enzyme which catalyzes the dismutation of superoxide radicals (O2·- + O2·- + 2H+ → O2 + H2O2) has been purified by a simple procedure from bovine erythrocytes. This enzyme, c...

The Utility of Superoxide Dismutase in Studying Free Radical Reactions

The superoxide dismutase (dismutase) which has already been found to be useful in detecting the role of O2·- in certain enzymic reactions has here been shown to be applicable to...

Hypertension and the Pathogenesis of Atherosclerosis

Abstract Hypertension is a risk factor for the development of atherosclerosis, although the mechanisms have not been well elucidated. As the cellular and molecular mechanisms of...

6-Hydroxydopamine: Evidence for Superoxide Radical as an Oxidative Intermediate

Superoxide dismutase inhibited the autoxidation of 6-hydroxydopamine as measured by the rate of formation of a quinone and the rate of oxygen consumption. These observations dem...

Role of nitric oxide in mediation of macrophage cytotoxicity and apoptosis