Abstract

The plasma concentration of aldosterone was followed in seven hypertensive patients before and during long-term angiotensin II suppression with the orally active angiotensin-I-converting-enzyme inhibitor, captopril. The plasma concentration of aldosterone decreased initially from 74 to 21 pg/ml ( P < 0·05) after 1 month of administration of captopril. Thereafter the plasma concentration of aldosterone began to rise and after 1 year reached a level of 165 pg/ml. During long-term captopril therapy the plasma renin activity remained increased and the plasma angiotensin II concentration suppressed. The mechanism responsible for the late rise of the plasma concentration of aldosterone during long-term angiotensin II suppression with captopril remains to be elucidated. A sizeable and lasting hypotensive effect was observed in all patients.

Keywords

CaptoprilAldosteroneInternal medicineEndocrinologyRenin–angiotensin systemAngiotensin IIPlasma renin activityChemistryAngiotensin-converting enzymePlasma concentrationMedicineBlood pressure

MeSH Terms

AdultAldosteroneAngiotensin IICaptoprilDepressionChemicalFemaleHumansHypertensionMaleMiddle AgedProlineReninTime Factors

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Publication Info

Year
1981
Type
article
Volume
91
Issue
3
Pages
457-465
Citations
333
Access
Closed

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Cite This

Jan A. Staessen, Paul Lijnen, R. Fagard et al. (1981). RISE IN PLASMA CONCENTRATION OF ALDOSTERONE DURING LONG-TERM ANGIOTENSIN II SUPPRESSION. Journal of Endocrinology , 91 (3) , 457-465. https://doi.org/10.1677/joe.0.0910457

Identifiers

DOI
10.1677/joe.0.0910457
PMID
7035596

Data Quality

Data completeness: 81%