Abstract

Abstract Rhea (https://www.rhea-db.org) is an expert-curated knowledgebase of biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of Biological Interest) (https://www.ebi.ac.uk/chebi). In this paper, we describe a number of key developments in Rhea since our last report in the database issue of Nucleic Acids Research in 2019. These include improved reaction coverage in Rhea, the adoption of Rhea as the reference vocabulary for enzyme annotation in the UniProt knowledgebase UniProtKB (https://www.uniprot.org), the development of a new Rhea website, and the designation of Rhea as an ELIXIR Core Data Resource. We hope that these and other developments will enhance the utility of Rhea as a reference resource to study and engineer enzymes and the metabolic systems in which they function.

Keywords

UniProtBiologyAnnotationComputational biologyResource (disambiguation)OntologyData scienceComputer scienceBioinformaticsGenetics

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Publication Info

Year
2021
Type
article
Volume
50
Issue
D1
Pages
D693-D700
Citations
213
Access
Closed

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Parit Bansal, Anne Morgat, Kristian B. Axelsen et al. (2021). Rhea, the reaction knowledgebase in 2022. Nucleic Acids Research , 50 (D1) , D693-D700. https://doi.org/10.1093/nar/gkab1016

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DOI
10.1093/nar/gkab1016