Abstract
It is now well established that regulatory T (T(R)) cells can inhibit harmful immunopathological responses directed against self or foreign antigens. However, many key aspects of T(R) cell biology remain unresolved, especially with regard to their antigen specificities and the cellular and molecular pathways involved in their development and mechanisms of action. We will review here recent findings in these areas, outline a model for how T(R) cells may inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of T(R) cell function.
Keywords
Immune systemBiologyImmunologyAntigenT cellFunction (biology)Cell biology
MeSH Terms
AbataceptAnimalsAntigensCDAntigensDifferentiationAutoimmune DiseasesCTLA-4 AntigenCell AdhesionCytokinesHumansImmunoconjugatesMiceModelsImmunologicalReceptorsInterleukin-2Self ToleranceT-Lymphocyte SubsetsT-LymphocytesRegulatoryThymus Gland
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Publication Info
- Year
- 2001
- Type
- review
- Volume
- 2
- Issue
- 9
- Pages
- 816-822
- Citations
- 1181
- Access
- Closed
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Cite This
Kevin J. Maloy,
Fiona Powrie
(2001).
Regulatory T cells in the control of immune pathology.
Nature Immunology
, 2
(9)
, 816-822.
https://doi.org/10.1038/ni0901-816
Identifiers
- DOI
- 10.1038/ni0901-816
- PMID
- 11526392