Abstract

The mechanism by which cell surface molecules regulate T cell production of lymphokines is poorly understood. Production of interleukin-2 (IL-2) can be regulated by signal transduction pathways distinct from those induced by the T cell antigen receptor. Stimulation of CD28, a molecule expressed on most human T cells, induced the formation of a protein complex that bound to a site on the IL-2 gene distinct from previously described binding sites and increased IL-2 enhancer activity fivefold. The CD28-responsive complex bound to the IL-2 gene between -164 and -154 base pairs from the transcription start site. The sequence of this element is similar to regions conserved in the 5′ flanking regions of several other lymphokine genes.

Keywords

EnhancerLymphokineCD28T-cell receptorBiologyGeneT cellInterleukin 2Cell biologySignal transductionMolecular biologyTranscription factorReceptorAntigenGeneticsImmune system

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Publication Info

Year
1991
Type
article
Volume
251
Issue
4991
Pages
313-316
Citations
640
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James D. Fraser, Bryan Irving, Gerald R. Crabtree et al. (1991). Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28. Science , 251 (4991) , 313-316. https://doi.org/10.1126/science.1846244

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DOI
10.1126/science.1846244