Abstract
[reaction: see text] Palladium-catalyzed directed C-H activation/oxygenation reactions have been explored in a series of meta-substituted aryl pyridine and aryl amide derivatives. These transformations tolerate a diverse array of electron-donating and electron-withdrawing meta-substituents and generally proceed with high levels of regioselectivity for functionalization of the less sterically hindered ortho-C-H bond.
Keywords
RegioselectivityChemistrySteric effectsPalladiumCatalysisArylAmidePyridineSurface modificationCombinatorial chemistryMedicinal chemistryOrganic chemistryAlkyl
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Publication Info
- Year
- 2005
- Type
- article
- Volume
- 7
- Issue
- 19
- Pages
- 4149-4152
- Citations
- 239
- Access
- Closed
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Cite This
Dipannita Kalyani,
Melanie S. Sanford
(2005).
Regioselectivity in Palladium-Catalyzed C−H Activation/Oxygenation Reactions.
Organic Letters
, 7
(19)
, 4149-4152.
https://doi.org/10.1021/ol051486x
Identifiers
- DOI
- 10.1021/ol051486x