Abstract

The somatic loss of heterozygosity for normal alleles occurring in human tumors has suggested the presence of recessive oncogenes. The results presented here demonstrate a loss of heterozygosity of several genes on chromosome 11 in primary breast tumors. Restriction fragment length polymorphism analysis of these DNAs further suggests that the most frequent loss of sequences in breast tumors occurs between the β-globin and parathyroid hormone loci on the short arm of chromosome 11. The loss of heterozygosity for chromosome 11 loci has a significant association with tumors that lack estrogen and progesterone receptors, grade III tumors, and distal metastasis.

Keywords

Loss of heterozygosityBiologyGeneticsAlleleChromosomeGeneCancer research

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Publication Info

Year
1987
Type
article
Volume
238
Issue
4824
Pages
185-188
Citations
326
Access
Closed

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Imran Ali, Rosette Lidereau, Charles Theillet et al. (1987). Reduction to Homozygosity of Genes on Chromosome 11 in Human Breast Neoplasia. Science , 238 (4824) , 185-188. https://doi.org/10.1126/science.3659909

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DOI
10.1126/science.3659909