Recycling of Cell-surface Receptors: Observations from the LDL Receptor System

Michael S. Brown; R G Anderson; S. Basu; J L Goldstein

doi:10.1101/sqb.1982.046.01.068

Abstract

During receptor-mediated endocytosis, extracellular ligands bind to plasma-membrane receptors and rapidly enter cells when the membrane invaginates and pinches off to form an endocytic vesicle. In many systems the receptors cluster in discrete regions of the plasma membrane, called coated pits, that invaginate to form clathrin-coated vesicles. The internalized vesicles rapidly lose their clathrin coats and eventually fuse with lysosomes (Goldstein et al. 1979; Pearse 1980).

Keywords

EndocytosisEndocytic cycleVesicleClathrinReceptorReceptor-mediated endocytosisCell biologyChemistryCell surface receptorCellCell membraneExtracellularMembraneBiophysicsBiochemistryBiology

Affiliated Institutions

University of Texas Health Science Center at Dallas US

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Publication Info

Year: 1982
Type: article
Volume: 46
Issue: 0
Pages: 713-721
Citations: 82
Access: Closed

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APA Style

                            
                                
                                    Michael S. Brown, 
                                
                                    R G Anderson, 
                                
                                    S. Basu
                                
                                et al.
                            
                            (1982). 
                            Recycling of Cell-surface Receptors: Observations from the LDL Receptor System. 
                            Cold Spring Harbor Symposia on Quantitative Biology
                            , 46
                            (0)
                            , 713-721.
                            https://doi.org/10.1101/sqb.1982.046.01.068
                        

Identifiers

DOI: 10.1101/sqb.1982.046.01.068