Reconstituting Organ-Level Lung Functions on a Chip

Dongeun Huh; Benjamin D. Matthews; Akiko Mammoto; Martin Montoya‐Zavala; Hong Yuan Hsin; Donald E. Ingber

doi:10.1126/science.1188302

Abstract

Just Breathe Design of artificial systems that mimic in vivo organs could provide a better alternative for understanding mechanisms underlying physiological responses than current cell-based models or animal tests. Huh et al. (p. 1662 ) have created a tissue-tissue interface of human-cultured epithelial cells and endothelial cells together, with extracellular matrix in a device that models the alveolar-capillary interface of the human lung. The device mimicked physiological organ-level functions, including pathogen-induced inflammatory responses and responses to cytokine exposure. Breathing-type movements affected acute pulmonary cell toxicity and proinflammatory activity of widely used nanoparticulates.

Keywords

Proinflammatory cytokineExtracellular matrixLungCell biologyOrgan-on-a-chipCytokineIn vivoExtracellularBiologyCell typeCellImmunologyInflammationMedicineInternal medicineBiochemistryNanotechnologyMaterials scienceBiotechnology

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Publication Info

Year: 2010
Type: article
Volume: 328
Issue: 5986
Pages: 1662-1668
Citations: 3918
Access: Closed

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APA Style

                            
                                
                                    Dongeun Huh, 
                                
                                    Benjamin D. Matthews, 
                                
                                    Akiko Mammoto
                                
                                et al.
                            
                            (2010). 
                            Reconstituting Organ-Level Lung Functions on a Chip. 
                            Science
                            , 328
                            (5986)
                            , 1662-1668.
                            https://doi.org/10.1126/science.1188302
                        

Identifiers

DOI: 10.1126/science.1188302