Abstract

ACE 2, a novel homologue of angiotensin converting enzyme, has recently been identified. This study used QRT‐PCR to quantitatively map the transcriptional expression profile of ACE 2 (and the two isoforms of ACE) in 72 human tissues. While confirming that ACE 2 expression is high in renal and cardiovascular tissues, the novel observation has been made that ACE 2 shows comparably high levels of expression in the gastrointestinal system, in particular in ileum, duodenum, jejunum, caecum and colon. Therefore, in probing the functional significance of this novel peptidase, some consideration should be given to a role in gastrointestinal physiology and pathophysiology.

Keywords

JejunumIleumDuodenumAngiotensin-converting enzymePathophysiologyBiologyRenin–angiotensin systemEnzymePeptidyl-Dipeptidase AGene isoformEndocrinologyInternal medicineMolecular biologyBiochemistryMedicineGene

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Publication Info

Year
2002
Type
article
Volume
532
Issue
1-2
Pages
107-110
Citations
868
Access
Closed

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Dan W. Harmer, Maureen Gilbert, Richard A. Borman et al. (2002). Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. FEBS Letters , 532 (1-2) , 107-110. https://doi.org/10.1016/s0014-5793(02)03640-2

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DOI
10.1016/s0014-5793(02)03640-2