Abstract

There is currently a lack of pathologic data on the novel coronavirus (severe acute respiratory syndrome coronavirus 2) pneumonia, or coronavirus disease 2019 (COVID-19), from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of the operation. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Because both patients did not exhibit symptoms of pneumonia at the time of operation, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.

Keywords

MedicinePathologyPneumoniaCoronavirusLungLung cancerHyalineAutopsyDiffuse alveolar damageAdenocarcinomaCoronavirus disease 2019 (COVID-19)Respiratory diseasePulmonary edemaViral pneumoniaRespiratory tractPulmonary pathologyCancerRespiratory systemDiseaseInternal medicineInfectious disease (medical specialty)

MeSH Terms

AdenocarcinomaAgedAged80 and overBetacoronavirusCOVID-19Coronavirus InfectionsFemaleHumansLungLung NeoplasmsMalePandemicsPneumoniaViralRetrospective StudiesSARS-CoV-2TomographyX-Ray Computed

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Publication Info

Year
2020
Type
article
Volume
15
Issue
5
Pages
700-704
Citations
1425
Access
Closed

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Cite This

Sufang Tian, Weidong Hu, Li Niu et al. (2020). Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer. Journal of Thoracic Oncology , 15 (5) , 700-704. https://doi.org/10.1016/j.jtho.2020.02.010

Identifiers

DOI
10.1016/j.jtho.2020.02.010
PMID
32114094
PMCID
PMC7128866

Data Quality

Data completeness: 86%