Keywords
Affiliated Institutions
Related Publications
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
The tumour-suppressor phosphatase with tensin homology (PTEN) is the most important negative regulator of the cell-survival signalling pathway initiated by phosphatidylinositol ...
A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival
PTEN Variations The product of the tumor suppressor gene phosphate and tensin homolog on chromosome ten ( PTEN) is a lipid and protein phosphatase that regulates important cellu...
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.
Serum and certain growth factors have the ability to inhibit programmed cell death (apoptosis) and promote survival. The mechanism by which growth factors deliver an anti-apopto...
The Phosphoinositide 3-Kinase Pathway
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of ph...
Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma
Abstract The classification of human tumors based on molecular criteria offers tremendous clinical potential; however, discerning critical and “druggable” effectors on a large s...
Publication Info
- Year
- 2002
- Type
- review
- Volume
- 12
- Issue
- 12
- Pages
- 579-585
- Citations
- 181
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1016/s0962-8924(02)02412-1