Keywords
BiologyProteasesComputational biologyDie (integrated circuit)Cell biologyGeneticsEnzymeBiochemistryMechanical engineeringEngineering
MeSH Terms
AnimalsApoptosisCysteine EndopeptidasesHumans
Affiliated Institutions
Related Publications
BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases
Expression of BAX, without another death stimulus, proved sufficient to induce a common pathway of apoptosis. This included the activation of interleukin 1β-converting enzyme (I...
The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death
Mitochondrial alterations including permeability transition (PT) constitute critical events of the apoptotic cascade and are under the control of Bcl-2 related gene products. He...
Conversion of Bcl-2 to a Bax-like Death Effector by Caspases
Caspases are a family of cysteine proteases implicated in the biochemical and morphological changes that occur during apoptosis (programmed cell death). The loop domain of Bcl-2...
Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak
There is increasing evidence for a central role in mammalian apoptosis of the interleukin-1β– converting enzyme (ICE) family of cysteine proteases, homologues of the product of ...
Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis
The caspase-3 (CPP32, apopain, YAMA) family of cysteinyl proteases has been implicated as key mediators of apoptosis in mammalian cells. Gelsolin was identified as a substrate f...
Publication Info
- Year
- 1998
- Type
- review
- Volume
- 12
- Issue
- 11
- Pages
- 1551-1570
- Citations
- 1231
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1231
OpenAlex
35
Influential
989
CrossRef
Cite This
Vincent L. Cryns,
Junying Yuan
(1998).
Proteases to die for.
Genes & Development
, 12
(11)
, 1551-1570.
https://doi.org/10.1101/gad.12.11.1551
Identifiers
- DOI
- 10.1101/gad.12.11.1551
- PMID
- 9620844