Abstract

We demonstrated that when categories of tumor infiltrating lymphocytes are strictly defined, they indeed have very strong predictive value for primary cutaneous melanomas with a vertical growth phase. This work confirms the work of Clark et al. and fully illustrates the brisk, nonbrisk, and absent categories of infiltration. Finally, a multivariate analysis comparing thickness, mitotic rate and presence of tumor infiltrating lymphocytes showed that only thickness and presence of tumor infiltrating lymphocytes are significant and independent positive histologic prognostic factors.

Keywords

MedicineMelanomaUnivariate analysisMitotic indexProportional hazards modelTumor-infiltrating lymphocytesPathologyCancerSurvival analysisOncologyBreslow ThicknessPrimary tumorMultivariate analysisInternal medicineMitosisMetastasisImmunotherapyCancer researchBreast cancerBiology

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Publication Info

Year
1996
Type
article
Volume
77
Issue
7
Pages
1303-1310
Citations
1120
Access
Closed

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Claudio G. Clemente, Martín C. Mihm, Rosaria Bufalino et al. (1996). Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer , 77 (7) , 1303-1310. https://doi.org/10.1002/(sici)1097-0142(19960401)77:7<1303::aid-cncr12>3.0.co;2-5

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DOI
10.1002/(sici)1097-0142(19960401)77:7<1303::aid-cncr12>3.0.co;2-5