Abstract

The relation between viremia and clinical outcome in individuals infected with human immunodeficiency virus-type 1 (HIV-1) has important implications for therapeutic research and clinical care. HIV-1 RNA in plasma was quantified with a branched-DNA signal amplification assay as a measure of viral load in a cohort of 180 seropositive men studied for more than 10 years. The risk of acquired immunodeficiency syndrome (AIDS) and death in study subjects, including those with normal numbers of CD4 + T cells, was directly related to plasma viral load at study entry. Plasma viral load was a better predictor of progression to AIDS and death than was the number of CD4 + T cells.

Keywords

ViremiaViral loadVirologyVirusHuman immunodeficiency virus (HIV)ImmunologyCohortMedicineRNAViral diseaseBiologyInternal medicineGeneticsGene

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Publication Info

Year
1996
Type
letter
Volume
272
Issue
5265
Pages
1167-1170
Citations
2694
Access
Closed

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John W. Mellors, Charles R. Rinaldo, Phalguni Gupta et al. (1996). Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma. Science , 272 (5265) , 1167-1170. https://doi.org/10.1126/science.272.5265.1167

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DOI
10.1126/science.272.5265.1167