Abstract
This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition. The factors that influence the formation of protein-protein complexes are explored in four different types of protein-protein complexes--homodimeric proteins, heterodimeric proteins, enzyme-inhibitor complexes, and antibody-protein complexes. The comparison between the complexes highlights differences that reflect their biological roles.
Keywords
Protein–protein interactionProtein structureProtein crystallizationChemistryBiochemistryBiologyComputational biology
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Publication Info
- Year
- 1996
- Type
- review
- Volume
- 93
- Issue
- 1
- Pages
- 13-20
- Citations
- 2641
- Access
- Closed
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Cite This
Susan R. Jones,
Janet M. Thornton
(1996).
Principles of protein-protein interactions..
Proceedings of the National Academy of Sciences
, 93
(1)
, 13-20.
https://doi.org/10.1073/pnas.93.1.13
Identifiers
- DOI
- 10.1073/pnas.93.1.13