Abstract

The most frequent primary brain tumours in adults are gliomas and primary CNS lymphomas. In gliomas, molecular genetic analysis plays an increasing part in classification and treatment planning, a feature well illustrated by the chemosensitive oligodendrogliomas. Unfortunately, management of glioblastoma is still mainly palliative. Incidence of primary CNS lymphoma has increased strikingly in the past 20 years; substantial progress has been achieved in patients who are immunocompetent with the addition of methotrexate-based chemotherapy to radiotherapy, but the potential neurotoxic effects of this combination in elderly patients is worrisome.

Keywords

MedicineRadiation therapyMethotrexateChemotherapyIncidence (geometry)LymphomaOncologyGliomaPrimary treatmentOligodendrogliomaInternal medicinePathologyCancer researchAstrocytoma

MeSH Terms

AdultBrain NeoplasmsCombined Modality TherapyGliomaHumansMagnetic Resonance ImagingMolecular Biology

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Publication Info

Year
2003
Type
review
Volume
361
Issue
9354
Pages
323-331
Citations
741
Access
Closed

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Cite This

Anthony Béhin, Khê Hoang‐Xuan, Alain Carpentier et al. (2003). Primary brain tumours in adults. The Lancet , 361 (9354) , 323-331. https://doi.org/10.1016/s0140-6736(03)12328-8

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DOI
10.1016/s0140-6736(03)12328-8
PMID
12559880

Data Quality

Data completeness: 81%