Abstract

The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.

Keywords

Innate immune systemBiologyImmunityAcquired immune systemEffectorIntrinsic immunityImmunologyImmune system

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Publication Info

Year
1999
Type
review
Volume
284
Issue
5418
Pages
1313-1318
Citations
2478
Access
Closed

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Jules A. Hoffmann, Fotis C. Kafatos, Charles A. Janeway et al. (1999). Phylogenetic Perspectives in Innate Immunity. Science , 284 (5418) , 1313-1318. https://doi.org/10.1126/science.284.5418.1313

Identifiers

DOI
10.1126/science.284.5418.1313