Phase II Study of Continuous Venous Infusion of 5-Fluorouracil in Advanced Pancreatic Cancer

Hisao Tajiri; Masayoshi Yoshimori; Nobuo Okazaki; Makoto Miyaji

doi:10.1159/000226887

Abstract

Continuous venous infusion of 5-fluorouracil (5FU) was investigated in 18 patients with measureable advanced cancer of the pancreas. 5FU was given for 7 days in a dose of 500 mg/m2 by continuous venous infusion over a 24-hour period and then followed by a dose of 170 mg/m2 for more than 28 days. Ten patients had no change including 1 patient with minor response, and 4 patients had disease progression. Serum CA19-9 levels were measured serially after chemotherapy in 13 of 14 evaluable patients. In 3 of 10 patients who showed high levels before treatment, serum CA19-9 levels were significantly decreasing after treatment.

Keywords

MedicineFluorouracilChemotherapyPancreatic cancerContinuous infusionInternal medicinePancreatic diseaseGastroenterologyCancerSurgeryPancreas

Affiliated Institutions

National Cancer Center US

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Publication Info

Year: 1991
Type: article
Volume: 48
Issue: 1
Pages: 18-21
Citations: 27
Access: Closed

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APA Style

                            
                                
                                    Hisao Tajiri, 
                                
                                    Masayoshi Yoshimori, 
                                
                                    Nobuo Okazaki
                                
                                et al.
                            
                            (1991). 
                            Phase II Study of Continuous Venous Infusion of 5-Fluorouracil in Advanced Pancreatic Cancer. 
                            Oncology
                            , 48
                            (1)
                            , 18-21.
                            https://doi.org/10.1159/000226887
                        

Identifiers

DOI: 10.1159/000226887