Personalized genomic analyses for cancer mutation discovery and interpretation

Abstract

Analysis of matched tumor and normal DNA from the same patient improves accuracy of identification of actionable mutations, allowing better targeting of potential treatments.

Keywords

Exome sequencingGermlineExomeGermline mutationSomatic cellMassive parallel sequencingCancerBiologyGeneticsGeneDNA sequencingMutationComputational biologyMedicine

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Publication Info

Year: 2015
Type: article
Volume: 7
Issue: 283
Pages: 283ra53-283ra53
Citations: 412
Access: Closed

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APA Style

                            
                                
                                    Siân Jones, 
                                
                                    Valsamo Anagnostou, 
                                
                                    Karli Lytle
                                
                                et al.
                            
                            (2015). 
                            Personalized genomic analyses for cancer mutation discovery and interpretation. 
                            Science Translational Medicine
                            , 7
                            (283)
                            , 283ra53-283ra53.
                            https://doi.org/10.1126/scitranslmed.aaa7161
                        

Identifiers

DOI: 10.1126/scitranslmed.aaa7161