Peginterferon Alfa-2a in Patients with Chronic Hepatitis C

Abstract

In patients with chronic hepatitis C, a regimen of peginterferon alfa-2a given once weekly is more effective than a regimen of interferon alfa-2a given three times weekly.

Keywords

MedicineRegimenChronic hepatitisGastroenterologyInterferon alfaPeginterferon alfa-2aHepatitis CAlpha interferonInternal medicineInterferonPolyethylene glycolImmunologyVirologyRibavirinVirusBiochemistry

MeSH Terms

AdultAntiviral AgentsDrug Administration ScheduleFemaleHepacivirusHepatitis CChronicHumansInjectionsSubcutaneousInterferon alpha-2Interferon-alphaLogistic ModelsMalePolyethylene GlycolsRNAViralRecombinant ProteinsTreatment Outcome

Affiliated Institutions

Related Publications

Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection

Michael Fried , Mitchell L. Shiffman , K. Rajender Reddy +11 more

BACKGROUND Treatment with peginterferon alfa-2a alone produces significantly higher sustained virologic responses than treatment with interferon alfa-2a alone in patients with c...

2002 New England Journal of Medicine 6384 citations

Peginterferon Alfa-2a in Patients with Chronic Hepatitis C and Cirrhosis

E. Jenny Heathcote , Mitchell L. Shiffman , W. Graham E. Cooksley +9 more

In patients with chronic hepatitis C and cirrhosis or bridging fibrosis, 180 microg of peginterferon alfa-2a administered once weekly is significantly more effective than 3 mill...

2000 New England Journal of Medicine 885 citations

A Randomized, Double–Blind Trial Comparing Pegylated Interferon Alfa–2B to Interferon Alfa–2B As Initial Treatment for Chronic Hepatitis C

Karen L. Lindsay , Christian Trépo , Tobias Heintges +8 more

This international, randomized, active–controlled, parallel–group, double–blind dose–finding study compared peginterferon alfa–2b (PegIntron™) to interferon alfa–2b for the init...

2001 Hepatology 666 citations

Long-term efficacy of ribavirin plus interferon alfa in the treatment of chronic hepatitis C

Lai My , Jia‐Horng Kao , Pei‐Ming Yang +5 more

Sustained response to interferon treatment for chronic hepatitis C is unsatisfactory. This study examined whether combining interferon alfa with ribavirin induces a better susta...

1996 Gastroenterology 247 citations

Efficacy and Safety of Pegylated (40–Kd) Interferon α–2A Compared With Interferon α–2A in Noncirrhotic Patients With Chronic Hepatitis C

K. Rajender Reddy , Teresa L. Wright , Paul J. Pockros +12 more

Administration of interferon (IFN) 3 times weekly in patients with chronic hepatitis C (CHC) is associated with low sustained responses, which may be, in part, related to this r...

2001 Hepatology 360 citations

Publication Info

Year: 2000
Type: article
Volume: 343
Issue: 23
Pages: 1666-1672
Citations: 1221
Access: Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric

Peginterferon Alfa-2a in Patients with Chronic Hepatitis C

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1221

OpenAlex

Influential

932

CrossRef

Cite This

APA Style

                            
                                
                                    Stefan Zeuzem, 
                                
                                    S.V. Feinman, 
                                
                                    J. Rasenack
                                
                                et al.
                            
                            (2000). 
                            Peginterferon Alfa-2a in Patients with Chronic Hepatitis C. 
                            New England Journal of Medicine
                            , 343
                            (23)
                            , 1666-1672.
                            https://doi.org/10.1056/nejm200012073432301
                        

Identifiers

DOI: 10.1056/nejm200012073432301
PMID: 11106715

Data Quality

Data completeness: 86%