Abstract
The constitutive fibrils of the Lewy body contain all three neurofilament subunits in an altered form. Our recent in situ hybridization studies of the low molecular weight subunit of the neurofilament suggest that altered neurofilament expression is not implicated in the formation of the Lewy body. Using the Mallory body of the liver as a dynamic model of intermediate filament inclusion formation, we also demonstrated that the filaments are first normally assembled and modified in a subsequent step. We propose a speculative model of Lewy body pathogenesis in which neurofilaments are assembled normally and subsequently undergo phosphorylation, proteolysis and crosslinking at a post-translational/post-assembly stage.
Keywords
NeurofilamentPathogenesisProtein subunitLewy bodyProteolysisIntermediate filamentCell biologyBiologyChemistryPathologyBiochemistryMedicineCytoskeletonCellImmunologyImmunohistochemistryParkinson's diseaseGene
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Publication Info
- Year
- 1996
- Type
- book-chapter
- Pages
- 302-307
- Citations
- 5
- Access
- Closed
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Cite This
Céline Bergeron,
Michael S. Pollanen
(1996).
Pathogenesis of the Lewy body.
Cambridge University Press eBooks
, 302-307.
https://doi.org/10.1017/cbo9780511601187.029
Identifiers
- DOI
- 10.1017/cbo9780511601187.029