p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

Katsutoshi Oda; Hirofumi Arakawa; Tomoaki Tanaka; Koichi Matsuda; Chizu Tanikawa; Toshiki Mori; Hiroyuki Nishimori; Katsuyuki Tamai; Takashi Tokino; Yusuke Nakamura; Yoichi Taya

doi:10.1016/s0092-8674(00)00073-8

Keywords

BiologyApoptosisPhosphorylationInhibitor of apoptosis domainCell biologyGeneMitochondrionProgrammed cell deathDNA damageMolecular biologyRegulation of gene expressionDNAGeneticsCaspase

Affiliated Institutions

Related Publications

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

Carmé Caelles , Arno Helmberg , Michael Karin

The tumour suppressor p53 is required to induce programmed cell death (apoptosis) by DNA-damaging agents. As p53 is a transcriptional activator that mediates gene induction afte...

1994 Nature 846 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Eri Oda , Rieko Ohki , Hideki Murasawa +6 more

A critical function of tumor suppressor p53 is the induction of apoptosis in cells exposed to noxious stresses. We report a previously unidentified pro-apoptotic gene, Noxa . Ex...

2000 Science 2071 citations

DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis

Diane Crighton , Simon Wilkinson , Jim O’Prey +7 more

Inactivation of cell death is a major step in tumor development, and p53, a tumor suppressor frequently mutated in cancer, is a critical mediator of cell death. While a role for...

2006 Cell 1333 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

M Debbas , Eileen White

Transformation of primary rodent cells by the adenovirus E1A and E1B oncogenes is a two-step process, where E1A-dependent induction of proliferation is coupled to E1B-dependent ...

1993 Genes & Development 873 citations

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

Ygal Haupt , Sheldon Rowan , Eitan Shaulian +2 more

The p53 tumor suppressor protein is a transcriptional activator, which can mediate apoptotic cell death in a variety of cell types. To determine whether sequence-specific trans-...

1995 Genes & Development 544 citations

Publication Info

Year: 2000
Type: article
Volume: 102
Issue: 6
Pages: 849-862
Citations: 1175
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1175

OpenAlex

Cite This

APA Style

                            
                                
                                    Katsutoshi Oda, 
                                
                                    Hirofumi Arakawa, 
                                
                                    Tomoaki Tanaka
                                
                                et al.
                            
                            (2000). 
                            p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53. 
                            Cell
                            , 102
                            (6)
                            , 849-862.
                            https://doi.org/10.1016/s0092-8674(00)00073-8
                        

Identifiers

DOI: 10.1016/s0092-8674(00)00073-8