p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

Vjekoslav Dulić; William K. Kaufmann; S J Wilson; Thea D. Tisty; Emma Lees; J. Wade Harper; Stephen J. Elledge; Steven I. Reed

doi:10.1016/0092-8674(94)90379-4

Keywords

BiologyCell biologyKinaseCancer researchCyclinCyclin-dependent kinaseCyclin-dependent kinase 4Cell cycleCyclin-dependent kinase 2Protein kinase AGeneticsApoptosis

Affiliated Institutions

Related Publications

Reprimo, a New Candidate Mediator of the p53-mediated Cell Cycle Arrest at the G2 Phase

Rieko Ohki , Jiro Nemoto , Hideki Murasawa +4 more

A novel gene, Reprimo, in which induction in cells exposed to X-irradiation is dependent on p53 expression, has been isolated. Ectopic p53 expression results in the induction of...

2000 Journal of Biological Chemistry 208 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Chu‐Xia Deng , Pumin Zhang , J. Wade Harper +2 more

p21CIP1/WAF1 is a CDK inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been suggested to derive anti-oncogenic properties from t...

1995 Cell 2106 citations

Gas1-Induced Growth Suppression Requires a Transactivation-Independent p53 Function

Giannino Del Sal , Elisabetta Ruaro , René Utrera +3 more

In normal cells, induction of quiescence is accompanied by the increased expression of growth arrest-specific genes (gas). One of them, gas1, is regulated at the transcriptional...

1995 Molecular and Cellular Biology 96 citations

The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein

Susana López-Borges , Pedro A. Lazo

The tumour suppressor p53 protein integrates multiple signals regulating cell cycle progression and apoptosis. This regulation is mediated by several kinases that phosphorylate ...

2000 Oncogene 168 citations

Association of the Cyclin-dependent Kinases and 14-3-3 Sigma Negatively Regulates Cell Cycle Progression

Christine Laronga , Heng-Yin Yang , Christopher L. Neal +1 more

14-3-3 sigma, implicated in cell cycle arrest by p53, was cloned by expression cloning through cyclin-dependent kinase 2 (CDK2) association. 14-3-3 sigma shares cyclin-CDK2 bind...

2000 Journal of Biological Chemistry 306 citations

Publication Info

Year: 1994
Type: article
Volume: 76
Issue: 6
Pages: 1013-1023
Citations: 1471
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1471

OpenAlex

Cite This

APA Style

                            
                                
                                    Vjekoslav Dulić, 
                                
                                    William K. Kaufmann, 
                                
                                    S J Wilson
                                
                                et al.
                            
                            (1994). 
                            p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. 
                            Cell
                            , 76
                            (6)
                            , 1013-1023.
                            https://doi.org/10.1016/0092-8674(94)90379-4
                        

Identifiers

DOI: 10.1016/0092-8674(94)90379-4