Abstract
Significance Aerobic life in humans imposes the hazard of excess oxidation in cell and tissue components that may compromise cell function and viability. The formation and accumulation of oxidized products in biomolecules such as proteins and lipids are observed in various pathologies and during the normal aging process. This review article aims to integrate some early and remarkable discoveries in the field, with more recent developments that helped to define a causative role of oxygen radicals, nitric oxide, and peroxynitrite in human physiology and pathology. These aspects of human redox biochemistry contribute to the understanding of the molecular basis of diseases and aging and open avenues for the development of preventive and therapeutic strategies in molecular medicine.
Keywords
PeroxynitriteNitric oxideRadicalRedoxChemistryBiochemistryBiologyCell biologySuperoxideEnzyme
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Publication Info
- Year
- 2018
- Type
- review
- Volume
- 115
- Issue
- 23
- Pages
- 5839-5848
- Citations
- 1021
- Access
- Closed
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Cite This
Rafael Radí
(2018).
Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine.
Proceedings of the National Academy of Sciences
, 115
(23)
, 5839-5848.
https://doi.org/10.1073/pnas.1804932115
Identifiers
- DOI
- 10.1073/pnas.1804932115