Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD

2018 New England Journal of Medicine 1,177 citations

Abstract

Triple therapy with fluticasone furoate, umeclidinium, and vilanterol resulted in a lower rate of moderate or severe COPD exacerbations than fluticasone furoate-vilanterol or umeclidinium-vilanterol in this population. Triple therapy also resulted in a lower rate of hospitalization due to COPD than umeclidinium-vilanterol. (Funded by GlaxoSmithKline; IMPACT ClinicalTrials.gov number, NCT02164513 .).

Keywords

LamaMuscarinic antagonistInhalerCOPDMedicineGlucocorticoidPulmonary diseaseAgonistInhalationAntagonistIndacaterolMuscarinic acetylcholine receptorInternal medicineAnesthesiaBronchodilatorAsthmaReceptor

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Publication Info

Year
2018
Type
article
Volume
378
Issue
18
Pages
1671-1680
Citations
1177
Access
Closed

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David A. Lipson, Frank Barnhart, Noushin Brealey et al. (2018). Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD. New England Journal of Medicine , 378 (18) , 1671-1680. https://doi.org/10.1056/nejmoa1713901

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DOI
10.1056/nejmoa1713901