Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

W. Michael Flanagan; Blaise Corthésy; Richard J. Bram; Robert H. Crabtree

doi:10.1038/352803a0

Keywords

Transcription factorFKBPProtein subunitProlyl isomeraseBiologyT cellCytoplasmCell biologyIntracellularIsomeraseMolecular biologyImmune systemBiochemistryGenePIN1Immunology

Affiliated Institutions

Stanford University US

Related Publications

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration

Yih‐Cherng Liou , Anyang Sun , Akihide Ryo +9 more

2003 Nature 432 citations

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

Lucia Pastorino , Anyang Sun , Pei‐Jung Lu +10 more

2006 Nature 489 citations

Cyclosporin A-Sensitive Transcription Factor Egr-3 Regulates Fas Ligand Expression

Paul R. Mittelstadt , Jonathan D. Ashwell

Activation-induced transcriptional upregulation of the ligand for Fas (FasL) and the resulting apoptosis of Fas-bearing cells constitute essential steps in a host of normal and ...

1998 Molecular and Cellular Biology 163 citations

Transcriptional Regulation of the Human FasL Promoter-Enhancer Region

Carrie J. Holtz‐Heppelmann , Alicia Algeciras , Andrew D. Badley +1 more

The human FasL enhancer region was cloned and functionally characterized in transformed and primary T cells. Within the 2.3 kilobase pairs of the FasL untranslated region, the d...

1998 Journal of Biological Chemistry 156 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

Dorothy Newmeyer

Apoptotic cell death involves a ritual series of morphological changes, presumably reflecting a conserved molecular pathway. We now report that the nuclear events typical of apo...

1994 Cell 577 citations

Publication Info

Year: 1991
Type: article
Volume: 352
Issue: 6338
Pages: 803-807
Citations: 1059
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1059

OpenAlex

Cite This

APA Style

                            
                                
                                    W. Michael Flanagan, 
                                
                                    Blaise Corthésy, 
                                
                                    Richard J. Bram
                                
                                et al.
                            
                            (1991). 
                            Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. 
                            Nature
                            , 352
                            (6338)
                            , 803-807.
                            https://doi.org/10.1038/352803a0
                        

Identifiers

DOI: 10.1038/352803a0