Abstract
A nonrandom pattern of chromosomal abnormalities occurs in bone marrow cells obtained from patients with hematologic disorders who have an abnormal karyotype involving a C group chromosome. An additional number 8 chromosome is the most common abnormality, found in more than one-half of the patients studies. An additional number 9 chromosome and the loss of all or part of a number 7 are abnormalities that occur more often than might be expected by chance. It is proposed that specific human chromosomal abnormalities may be related to different specific etiologic agents.
Keywords
KaryotypeAbnormalityChromosomeChromosomal AbnormalityBiologyHematologic disordersChromosome abnormalityBone marrowGeneticsPathologyImmunologyMedicineGene
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Publication Info
- Year
- 1975
- Type
- article
- Volume
- 72
- Issue
- 1
- Pages
- 152-156
- Citations
- 140
- Access
- Closed
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Cite This
Janet D. Rowley
(1975).
Nonrandom chromosomal abnormalities in hematologic disorders of man..
Proceedings of the National Academy of Sciences
, 72
(1)
, 152-156.
https://doi.org/10.1073/pnas.72.1.152
Identifiers
- DOI
- 10.1073/pnas.72.1.152