NLRP3 inflammasome activation drives tau pathology

Christina Ising; Carmen Venegas; Shuangshuang Zhang; Hannah Scheiblich; Susanne V. Schmidt; Ana Vieira‐Saecker; Stephanie Schwartz; Shadi Albasset; Róisín M. McManus; Darío Tejera; Angelika Griep; Francesco Santarelli; Frederic Brosseron; Sabine Opitz; James Stunden; Maximilian Merten; Rakez Kayed; Douglas T. Golenbock; David Blum; Eicke Latz; Luc Buée; Michael T. Heneka

doi:10.1038/s41586-019-1769-z

Keywords

InflammasomeTau pathologyPathologyNeuroscienceMedicineBiologyChemistryInflammationImmunologyDiseaseAlzheimer's disease

Affiliated Institutions

Related Publications

Inflammation as a central mechanism in Alzheimer's disease

Jefferson W. Kinney , Shane M. Bemiller , Andrew S. Murtishaw +3 more

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaq...

2018 Alzheimer s & Dementia Translational ... 2108 citations

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Erik D. Roberson , Kimberly Scearce‐Levie , Jorge J. Palop +6 more

Many potential treatments for Alzheimer's disease target amyloid-β peptides (Aβ), which are widely presumed to cause the disease. The microtubule-associated protein tau is also ...

2007 Science 1837 citations

Human amyloid β‐induced neuroinflammation is an early event in neurodegeneration

Jeffrey M. Craft , D. Martin Watterson , Linda J. Van Eldik

Abstract Using a human amyloid β (Aβ) intracerebroventricular infusion mouse model of Alzheimer's disease‐related injury, we previously demonstrated that systemic administration...

2005 Glia 109 citations

Targeting the NLRP3 inflammasome in inflammatory diseases

Matthew Mangan , Edward J. Olhava , William Roush +3 more

Danger signals are a hallmark of many common inflammatory diseases, and these stimuli can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR- ...

2018 Nature Reviews Drug Discovery 1783 citations

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

Nathan Kelley , Devon Jeltema , Yanhui Duan +1 more

The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in respo...

2019 International Journal of Molecular Sc... 3150 citations

Publication Info

Year: 2019
Type: article
Volume: 575
Issue: 7784
Pages: 669-673
Citations: 1393
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

NLRP3 inflammasome activation drives tau pathology

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1393

OpenAlex

Cite This

APA Style

                            
                                
                                    Christina Ising, 
                                
                                    Carmen Venegas, 
                                
                                    Shuangshuang Zhang
                                
                                et al.
                            
                            (2019). 
                            NLRP3 inflammasome activation drives tau pathology. 
                            Nature
                            , 575
                            (7784)
                            , 669-673.
                            https://doi.org/10.1038/s41586-019-1769-z
                        

Identifiers

DOI: 10.1038/s41586-019-1769-z