New Sesquiterpene α-Methylene Lactones from the Egyptian Plant Jasonia candicans

Abstract

Extracts of the plant Jasonia candicans possess antimicrobial activity. ET2O/MeOH extracts were subjected to liquid chromatography, and several sesquiterpenes were isolated and identified including the known compounds confertin [1], 4,11(13)-eudesmadien-12-oic acid [2], and 11-eudesmen-4-ol [3]. Two new diol alpha-methylene lactone antimicrobial agents were identified from nmr and mass spectral data and X-ray crystallography as (4 alpha, 5 alpha, 8 beta, 10 beta)-4,10-dihydroxy-1,11(13)-guaidien-12,8-olide [4] and (4 alpha, 5 alpha, 8 beta, 10 alpha)-4,10-dihydroxyl-1,11 (13)-guaidien-12,8-olide[5], which differ in stereochemistry at the C-10 tertiary alcohol center.

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Affiliated Institutions

Minia University EG

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Publication Info

Year: 1993
Type: article
Volume: 56
Issue: 8
Pages: 1276-1280
Citations: 69
Access: Closed

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APA Style

                            
                                
                                    Ahmed A. Ahmed, 
                                
                                    Ahmed A. Mahmoud, 
                                
                                    Howard J. Williams
                                
                                et al.
                            
                            (1993). 
                            New Sesquiterpene α-Methylene Lactones from the Egyptian Plant Jasonia candicans. 
                            Journal of Natural Products
                            , 56
                            (8)
                            , 1276-1280.
                            https://doi.org/10.1021/np50098a011
                        

Identifiers

DOI: 10.1021/np50098a011