Neutrophils in the activation and regulation of innate and adaptive immunity

Alberto Mantovani; Marco A. Cassatella; Claudio Costantini; Sébastien Jaillon

doi:10.1038/nri3024

Keywords

Innate immune systemEffectorAcquired immune systemImmune systemBiologyImmunologyNeutrophil extracellular trapsAutoimmunityInflammationPathogenesisCell biology

Affiliated Institutions

Related Publications

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

Carlos Rosales

Neutrophils are the most abundant leukocytes in the circulation, and have been regarded as first line of defense in the innate arm of the immune system. They capture and destroy...

2018 Frontiers in Physiology 1236 citations

Neutrophil Extracellular Traps Kill Bacteria

Volker Brinkmann , Ulrike Reichard , Christian Goosmann +5 more

Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and...

2004 Science 9596 citations

Expression of Toll-Like Receptors in Human Atherosclerotic Lesions

Kristina Edfeldt , Jesper Swedenborg , Göran K. Hansson +1 more

Background — Innate immune reactions against bacteria and viruses have been implicated in the pathogenesis of atherosclerosis. To explore the molecular mechanism by which microb...

2002 Circulation 693 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

Hans D. Brightbill , Daniel H. Libraty , Stephan R. Krutzik +11 more

The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for ...

1999 Science 1652 citations

Selective Roles for Toll-Like Receptor (TLR)2 and TLR4 in the Regulation of Neutrophil Activation and Life Span

Ian Sabroe , Lynne R. Prince , Elizabeth C. Jones +5 more

Abstract Neutrophil responses to commercial LPS, a dual Toll-like receptor (TLR)2 and TLR4 activator, are regulated by TLR expression, but are amplified by contaminating monocyt...

2003 The Journal of Immunology 339 citations

Publication Info

Year: 2011
Type: review
Volume: 11
Issue: 8
Pages: 519-531
Citations: 2873
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Neutrophils in the activation and regulation of innate and adaptive immunity

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

2873

OpenAlex

Cite This

APA Style

                            
                                
                                    Alberto Mantovani, 
                                
                                    Marco A. Cassatella, 
                                
                                    Claudio Costantini
                                
                                et al.
                            
                            (2011). 
                            Neutrophils in the activation and regulation of innate and adaptive immunity. 
                            Nature reviews. Immunology
                            , 11
                            (8)
                            , 519-531.
                            https://doi.org/10.1038/nri3024
                        

Identifiers

DOI: 10.1038/nri3024