Abstract
Two patients with levodopa-responsive Parkinson's syndrome had numerous cortical and striatal senile plaques and some neurofibrillary tangles at necropsy. In addition neurons in the pars compacta of the substantia nigra were severely depleted but there were no Lewy bodies or other neuropathological changes to account for parkinsonism. Neither patient was demented. These pathological findings have not previously been described as a cause of Parkinson's syndrome without associated dementia of Alzheimer's disease type.
Keywords
Pars compactaSubstantia nigraSenile plaquesParkinsonismPathologicalDiseasePathologyDementiaMedicineDegenerative diseaseNeuroscienceAlzheimer's diseasePsychologyParkinson's disease
Affiliated Institutions
Related Publications
Clinical and Pathological Aspects of Parkinsonism in Alzheimer's Disease
To examine the natural history and pathogenesis of parkinsonism in Alzheimer's disease, 44 subjects with clearly established senile dementia of the Alzheimer type were studied d...
STRIATONIGRAL DEGENERATION
The clinical and pathological features of 10 cases of striatonigral degeneration are described: 5 were misdiagnosed in life as Parkinson's disease. Retrospectively, helpful earl...
Tau is essential to β-amyloid-induced neurotoxicity
Senile plaques and neurofibrillary tangles, the two hallmark lesions of Alzheimer's disease, are the results of the pathological deposition of proteins normally present througho...
Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease
Immunocytochemistry with antibodies to ubiquitin is currently the most sensitive method for detecting cortical Lewy bodies, which are a sine qua non for the diagnosis of diffuse...
Clinically diagnosed Alzheimer's disease: Autopsy results in 150 cases
Abstract One hundred fifty autopsy brains from patients with clinically diagnosed Alzheimer's disease (AD) were examined pathologically. The brains were received consecutively o...
Publication Info
- Year
- 1991
- Type
- article
- Volume
- 54
- Issue
- 11
- Pages
- 972-975
- Citations
- 21
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
21
OpenAlex
Cite This
S. E. Daniel,
Andrew J. Lees
(1991).
Neuropathological features of Alzheimer's disease in non-demented parkinsonian patients..
Journal of Neurology Neurosurgery & Psychiatry
, 54
(11)
, 972-975.
https://doi.org/10.1136/jnnp.54.11.972
Identifiers
- DOI
- 10.1136/jnnp.54.11.972